Key result
MyBP-C slow is a family of phosphoproteins phosphorylated by PKA (Ser-59, Ser-62) and PKC (Ser-83, Thr-84), with phosphorylated levels notably increased in mouse dystrophic muscles.
MyBP-C slow is a novel phosphoprotein substrate for PKA and PKC, with altered phosphorylation levels in dystrophic skeletal muscle, suggesting a regulatory role in normalcy and disease.
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Phosphorylation of MyBP-C slow may regulate skeletal muscle in dystrophy; leaves open functional validation and therapeutic targeting.
Ackermann et al. (2011) studied Muscular dystrophy. MyBP-C slow is a family of phosphoproteins phosphorylated by PKA (Ser-59, Ser-62) and PKC (Ser-83, Thr-84), with phosphorylated levels notably increased in mouse dystrophic muscles.
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