Highlight discusses AI systems' tensions in autonomy and reproducibility for spatial omics analysis, suggesting defined autonomy is key.
This highlight summarises recent advances in agentic artificial intelligence (AI) systems for spatial omics analysis. These systems are compared along two central tensions: autonomy versus accountability, and adaptability versus reproducibility. We argue that progress will depend not on maximising automation, but on defining where autonomy is appropriate.
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Pavilion et al. (2026) studied this question.
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