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July 8, 2026Annals of HematologyOpen Access

Flow cytometric analysis of T-cell subsets and platelet surface markers in patients with immune thrombocytopenia: a case-control study

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Authors

MKMerve KaraPAPelin AytanCGCemil Gülüm

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Overview

Case-control study evaluates T-cell and platelet marker changes in chronic immune thrombocytopenia patients, suggesting immune dysregulation.

Key Points

  • This study aims to analyze the differences in T-cell subsets and platelet surface markers between patients with chronic immune thrombocytopenia and healthy controls.
  • Prospective case-control study with 26 chronic ITP patients and 25 healthy controls.
  • Flow cytometric analysis of T-cell populations including CD3+, CD4+, CD8+, and platelet markers such as CD41 and CD61.
  • Statistical analyses were performed using SPSS version 22.
  • ITP patients showed lower platelet counts (97,038 vs. 256,920/µL, p < 0.001) and higher mean platelet volumes (11.67 vs. 10.46 fL, p = 0.001).
  • CD45RA+/CD4+ ratios were lower in ITP patients (10.52% vs. 14.45%, p = 0.038).
  • Reduced expressions of CD41 and CD61 were observed in ITP patients (p < 0.001 for both).

Cite This Study

Kara et al. (2026) studied this question.

synapsesocial.com/papers/6a4de7d8d2ea289ef6282caehttps://doi.org/10.1007/s00277-026-07148-0
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