What question did this study set out to answer?

The aim is to evaluate the in vivo efficacy of peptoid oligomers against HSV-1 infections.

In Vivo Activity of Antimicrobial Peptoid Oligomers against HSV-1 in a Mouse Model of Herpes Labialis

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Randomized trial tests topical peptoid treatment for herpes labialis, indicating potential as new antiviral agents.

The aim is to evaluate the in vivo efficacy of peptoid oligomers against HSV-1 infections.
Utilized a lip treatment model of HSV-1 infection in BALB/c mice.
Administered clinical isolate of HSV-1 to scarified lips and treated with varying concentrations of peptoid.
Measured lesion formation and viral DNA levels using qPCR.
Peptoid treatment showed dose-dependent inhibition of lesion formation, comparable to acyclovir cream.
Quantification of viral DNA from lip and trigeminal ganglion confirmed significant reduction with peptoids.
Peptoids demonstrated the potential to serve as effective topical antiviral agents for HSV-1.

Figgins et al. (2026) studied this question.

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