Synthetic microbial community (SynCom) biosensors are emerging from the convergence of whole-cell biosensing, synthetic ecology, and computational design. Conventional whole-cell biosensors (WCBs) use a single microbial chassis to convert analyte recognition into optical, electrochemical, gaseous, or growth-linked outputs. This compact architecture supports low-cost and field-oriented detection, but it can be limited by cellular burden, narrow dynamic range, environmental interference, and difficulty in interpreting multicomponent signals. Natural microbial consortia provide an ecological template in which sensing, transformation, stress tolerance, and response are distributed across interacting populations. SynCom biosensors seek to translate this logic into engineered platforms with defined members, assigned functional roles, designed communication, and interpretable readouts. This review traces the transition from WCBs to natural consortia and engineered multicellular biosensors, emphasizing functional partitioning, signal routing, community control, and artificial intelligence (AI)-assisted design. AI is discussed as a practical tool for narrowing design space, predicting interactions, decoding complex biosignals, and supporting adaptive operation. Key challenges remain in community stability, orthogonal communication, data quality, biosafety, standardization, and real-sample validation. Future progress will depend on parsimonious community design, reliable containment, quantitative validation, and computational workflows that connect community composition with sensing performance.
Hu et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: