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This study aims to assess the feasibility of upfront surgical resection for advanced gallbladder carcinoma based on clinical T staging.

Feasibility of Surgical Resection for Advanced Gallbladder Carcinoma Based on Preoperative Clinical T Stagings: A Multicenter Retrospective Analysis ( SNOW ‐22‐05)

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This study aims to assess the feasibility of upfront surgical resection for advanced gallbladder carcinoma based on clinical T staging.
Retrospective analysis of 300 patients with cT3 or cT4 gallbladder carcinoma from six Japanese centers (2010-2022).
Comparison of resection rates, perioperative outcomes, and overall survival between cT3 and cT4 groups.
Among 300 patients, 260 (87%) underwent resection; benign lesions were found in 21 (8%) patients.
Higher rates of extended resection in cT4 compared to cT3 (75% vs. 40%, p < 0.001).
Median overall survival was significantly shorter for cT4 patients (22 months) compared to cT3 (44 months, p < 0.001).

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Retrospective analysis evaluates upfront resection feasibility in advanced gallbladder carcinoma, indicating important staging implications.

Kato et al. (2026) studied this question.

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Retrospective analysis evaluates upfront resection feasibility in advanced gallbladder carcinoma, indicating important staging implications.