Demonstrates improved allergic dermatitis outcomes in a mouse model, suggesting effective localized treatment strategies.
Allergic dermatitis (AD) requires long‐term management, yet conventional systemic therapies are frequently limited by adverse effects and inadequate lesion‐specific delivery. Herein, we report a mechanically reinforced composite dissolvable microneedle (MN) patch (L‐Cys@HAMN) for localized endogenous thiol delivery in AD treatment. The patch consists of L‐cysteine‐loaded hyaluronic acid (HA) microneedle tips integrated with an elastic poly(n‐butyl acrylate) (PBA) backing layer, enabling efficient force transmission and consistent skin penetration while minimizing structural deformation. Upon insertion, the dissolvable MN tips rapidly release L‐cysteine into the viable epidermis, where it is enzymatically converted into hydrogen sulfide (H 2 S) to suppress inflammatory responses. In vitro studies demonstrated significant downregulation of proinflammatory cytokines, including TNF‐α and IL‐6. In a passive cutaneous anaphylaxis mouse model, L‐Cys@HAMN markedly alleviated inflammatory infiltration and reduced local inflammatory burden compared with control treatments. In addition, the HA‐based matrix provided auxiliary moisturizing and barrier‐supporting effects. Collectively, this work presents a mechanically robust and therapeutically effective MN platform for localized endogenous thiol delivery and offers a promising strategy for AD management.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: