Analytical review defines light-chain smoldering multiple myeloma prevalence and progression in a population, suggesting a need for clearer classifications.
Smoldering multiple myeloma (SMM) is a precursor to multiple myeloma (MM) and present in 0.5% of the population over 40 years old [ 1 , 2 ]. In 10–20% of MM patients, the clonal BMPC do not produce intact M proteins but only free light chains (FLC) [ 3 , 4 ]. This subgroup termed light-chain MM and well-characterized, but light-chain SMM is not clearly defined.
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Maeng et al. (2026) studied this question.
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