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July 8, 2026Pediatric Dermatology

Can Systemic Treatment for Childhood Psoriasis Be Stopped in Cases of Remission? Data From the ACMe Cohort

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Authors

ARAhmad RachedYMYuyun MiaoABAlain Beauchet

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Overview

Randomized trial examines treatment cessation outcomes in pediatric patients with psoriasis, suggesting low relapse risk.

Key Points

  • This study aims to assess the feasibility of stopping systemic therapy in children with psoriasis who achieve clinical remission.
  • Retrospective analysis of the ACMe cohort study involving 433 children with moderate‐to‐severe psoriasis.
  • Evaluation of predictors for treatment discontinuation and remission through a multicenter, international real‐world study.
  • Patients followed for up to 6 months post-treatment cessation to monitor the need for further systemic therapy.
  • 79 out of 433 patients (18.2%) successfully discontinued systemic treatment due to remission.
  • Of those, 70 patients (88.6%) remained off systemic therapy for at least 6 months.
  • Younger age and lower baseline psoriasis severity were predictors for treatment discontinuation due to remission.

Cite This Study

Rached et al. (2026) studied this question.

synapsesocial.com/papers/6a4de871d2ea289ef628328chttps://doi.org/10.1111/pde.70313
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of Discontinuation and Re‐Initiation of Biologic Therapies in Psoriasis: Real‐World Data2026 · 2 citations
  2. 2Clinical and Demographic Characteristics of Pediatric Patients With Psoriasis: Age‐Related Variations and Remission Predictors2025
  3. 3Treatment response to systemic therapies in pediatric-onset versus adult-onset psoriasis: a longitudinal real-world study2026
  4. 4Treatment Discontinuation in Patients with Psoriasis Treated with Biologics: A Retrospective Analysis of German Health Claims Data2024 · 4 citations
  5. 5Long‐term safety and efficacy in paediatric psoriasis: Remaining challenges2026