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This study aims to clarify the prevalence of pregnancy complications in women diagnosed with polycythemia vera.

The Effect of Polycythemia Vera on Pregnancy Complications. The Analysis of an American Population Database With Over 9 Million Deliveries

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This study aims to clarify the prevalence of pregnancy complications in women diagnosed with polycythemia vera.
Conducted a retrospective cohort study using the HCUP‐NIS database from 2004 to 2014.
Identified pregnancies with polycythemia vera (PV) using ICD‐9 codes; controls were other pregnancies.
Cohort included 104 pregnancies with PV and 9,096,684 control pregnancies.
PV significantly associated with preeclampsia (aOR = 2.27; 95% CI = 1.04–4.97).
Found strong links to preterm premature rupture of membranes (aOR = 4.47; 95% CI = 1.78–11.21) and blood transfusion (aOR = 3.34; 95% CI = 1.17–9.55).
Maternal death linked to PV (aOR = 108.79; 95% CI = 14.37–823.88) although rare, warrants cautious interpretation.

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Retrospective cohort study analyzes pregnancy complications in women with polycythemia vera, indicating increased risks.

Margolese et al. (2026) studied this question.

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