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July 8, 2026Open Forum Infectious DiseasesOpen Access

Neurological manifestations of Mycoplasma pneumoniae infection in hospitalized adults during the 2023–2024 French epidemic, clinical characterisation and comparative outcomes: a multicentre study

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Authors

MHMatthieu HolubAGA GavaudCLCéline Louapre

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Overview

Multicentre study characterizes neurological outcomes in adults hospitalized for Mycoplasma pneumoniae infection, suggesting severe impacts on clinical course.

Key Points

  • This study aims to characterize neurological manifestations associated with Mycoplasma pneumoniae infection in adults during a recent epidemic.
  • Analyzed data from the national MYCADO cohort of 1,309 adults hospitalized during the 2023–2024 epidemic.
  • Conducted a retrospective review of medical records and clinical follow-up up to three months post-discharge.
  • Identified 28 patients (2.1% of the cohort) with neurological manifestations, with 19 affecting the central nervous system.
  • Patients with neurological involvement had longer hospital stays (13 days) compared to those without (9 days, p<0.001).
  • Neurological sequelae persisted in 36.8% of central nervous system patients and all Guillain-Barré syndrome patients after three months.

Cite This Study

Holub et al. (2026) studied this question.

synapsesocial.com/papers/6a4de93fd2ea289ef6283890https://doi.org/10.1093/ofid/ofag406
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>Mycoplasma pneumoniae</i> -associated central nervous system manifestations: current knowledge and challenges2026
  2. 2Movement Disorders and Cerebellar Syndromes Associated with <i>Mycoplasma pneumoniae</i> Infection: A Systematic Review2026
  3. 3Cardiac Manifestations of <i>Mycoplasma pneumoniae</i> Infections: A Cohort Study 2007–20242025 · 3 citations
  4. 4P-462. Temporal Clustering of Mycoplasma pneumoniae–Associated Encephalitis and Stroke in Children: A Multicenter Study During a Post-COVID-19 Epidemic2026
  5. 5Clinical Presentation of Pediatric Mycoplasma pneumoniae Before and After the COVID-19 Pandemic2025