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This study aims to identify risk factors associated with obstetric care and newborn evaluation that predict congenital syphilis.

July 8, 2026Discover Public HealthOpen Access

Determinants of obstetric and neonatal care for congenital syphilis confirmed by treponemal test in clinical follow-up at a r reference outpatient clinic

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Retrospective cohort study identifies factors predicting congenital syphilis in newborns, indicating treatment challenges for mothers.

This study aims to identify risk factors associated with obstetric care and newborn evaluation that predict congenital syphilis.
Retrospective cohort study conducted in a reference center for infectious diseases in Brazil from 2017 to 2022.
Included children exposed to vertical transmission of syphilis with confirmed diagnoses based on treponemal test results after 18 months.
Descriptive and comparative analysis performed between groups with confirmed and excluded congenital syphilis.
Absence of maternal treatment with benzathine penicillin was associated with a higher risk (OR = 4.29; CI 95% 1.13–18.96).
Presence of clinical manifestations in infants showed a significant association (OR = 4.97; CI 95% 1.30–18.96).
VDRL titration of the newborn collected at the maternity > 1:2 was strongly associated (OR = 11.28; CI 95% 1.42–94.44).

Pascoal et al. (2026) studied this question.

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