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July 8, 2026British Journal of Pharmacology

Tangeretin ameliorates sepsis‐induced neurocognitive impairment in adult male mice by suppressing Akt‐driven glycolytic reprogramming and neuroinflammation

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Authors

JWJue-Xian WeiHMHaifeng MaoHMHengzong Mo

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Overview

Randomized trial shows tangeretin reduces neuroinflammation and cognitive deficits in mice, suggesting a therapeutic role for sepsis recovery.

Key Points

  • The study aims to determine if tangeretin can prevent neurocognitive deficits caused by sepsis and to explore the mechanisms involved.
  • Sepsis was induced in mice via cecal ligation and puncture.
  • Mice received tangeretin (15 or 30 mg·kg−1·day−1) immediately post-surgery.
  • Cognitive function was assessed using Morris water maze and novel object recognition tests.
  • Tangeretin improved cognitive deficits in sepsis mice.
  • It decreased hippocampal microglial activation and proinflammatory cytokine levels.
  • Tangeretin inhibited Akt signaling and reduced glycolysis in microglia, correlating with decreased inflammation.

Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/6a4de9e4d2ea289ef6283d4fhttps://doi.org/10.1111/bph.70477
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway2024 · 27 citations
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  3. 3An Update on the Potential of Tangeretin in the Management of Neuroinflammation-Mediated Neurodegenerative Disorders2024 · 14 citations
  4. 4Taurine reverses long-term memory deficits caused by LPS induced neuroinflammation2026
  5. 5Minocycline mitigates sepsis‐induced neuroinflammation and promotes recovery in male mice: Insights into neuroprotection and inflammatory modulation2024 · 4 citations