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This study investigates the expression and function of SLC25A43 in hepatocellular carcinoma (HCC).

July 8, 2026Scientific ReportsOpen Access

SLC25A43 in hepatocellular carcinoma: bioinformatics insights into progression and immune microenvironment

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This study investigates the expression and function of SLC25A43 in hepatocellular carcinoma (HCC).
Utilized multi-omics data from TCGA-LIHC, GEO, and HPA for integrated bioinformatic analyses.
Conducted survival analyses to assess SLC25A43 as a prognostic factor.
Performed experimental validation in HCC cell lines (Huh-7, Hep-LM3, MHCC97H, LO2).
SLC25A43 was upregulated in HCC tissues with an AUC of 0.861 for diagnostic value.
High SLC25A43 expression correlated with advanced tumor stage and poor survival outcomes.
Knockdown of SLC25A43 inhibited cell proliferation and migration, while overexpression had the opposite effect.

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Bioinformatics analysis investigates the role of SLC25A43 in hepatocellular carcinoma, suggesting implications for treatment and prognosis.

Chen et al. (2026) studied this question.

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Bioinformatics analysis investigates the role of SLC25A43 in hepatocellular carcinoma, suggesting implications for treatment and prognosis.