Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 8, 2026Letters in Applied Microbiology

High glucose drives metabolic reprogramming toward stress resistance in Zygosaccharomyces mellis

View Full Paper
Ask AI
Bookmark
Share

Authors

TTTomoko Tamura

Discussion

Loading...

Member takes

Overview

Demonstrates how high glucose alters gene expression for stress resistance in yeast, indicating adaptive mechanisms.

Key Points

  • The aim is to understand how Zygosaccharomyces mellis adapts at the genetic level to high-glucose conditions and osmotic stress.
  • Conducted transcriptomic analysis of Zygosaccharomyces mellis under 50% glucose conditions.
  • Identified changes in gene expression related to metabolism and stress response.
  • Examined effects on growth in mutant strains of Saccharomyces cerevisiae.
  • Downregulation of glycolysis genes GAL7 and FBP1; upregulation of PYC2 linked to TCA cycle.
  • Altered membrane lipid metabolism with downregulation of AGPAT and PLPP; upregulation of ASM.
  • Impaired growth of Δmmr1 and Δhxt4 mutants under high glucose, highlighting metabolic pathway adaptations.

Cite This Study

Tomoko Tamura (2026) studied this question.

synapsesocial.com/papers/6a4de9e4d2ea289ef6283e70https://doi.org/10.1093/lambio/ovag057
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High Glucose Is a Stimulation Signal of the Salt–Tolerant Yeast Zygosaccharomyces rouxii on Thermoadaptive Growth2024 · 9 citations
  2. 2Yeast cell responses and survival during periodic osmotic stress are controlled by glucose availability2024
  3. 3Yeast cell responses and survival during periodic osmotic stress are controlled by glucose availability2024 · 1 citations
  4. 4Metabolomic insights into functional protein mediated salt stress adaptation in the osmophilic yeast Zygosaccharomyces rouxii2026
  5. 5Physiological Basis for the Tolerance of Yeast Zygosaccharomyces bisporus to Salt Stress2018