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July 8, 2026

Differential histopathological features and comorbidity profiles in chronic rhinosinusitis phenotypes.

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Authors

AMAlex Iulian MileaAFAstrid FrâncuAMAndreea Elena Milea

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Overview

Retrospective analysis reveals distinct inflammatory profiles in chronic rhinosinusitis types, highlighting treatment implications.

Key Points

  • This research aims to analyze histopathological changes and comorbidity profiles linked to Type 2 inflammation in chronic rhinosinusitis patients.
  • Retrospective, observational study conducted from January 2021 to December 2022
  • Enrolled 186 patients: 119 with chronic rhinosinusitis with nasal polyps (CRSwNP) and 67 without (CRSsNP)
  • Endoscopic sinus surgery performed for all participants with biopsy sample analysis.
  • Among CRSwNP patients, 27 (23%) had asthma; in CRSsNP, only 2 (3.03%) had asthma.
  • In CRSsNP, 18 (27%) showed hypereosinophilia; among CRSwNP, 56 (47%) did.
  • Eosinophilic infiltration was found in 73 (61%) CRSwNP biopsy samples.

Cite This Study

Milea et al. (2026) studied this question.

synapsesocial.com/papers/6a4dea28d2ea289ef6283f71https://doi.org/10.47162/rjme.67.1.18
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical, laboratory, and histopathological factors associated with revision surgery in chronic rhinosinusitis with nasal polyps.2026
  2. 2Prevalence of type 2 inflammation in chronic rhinosinusitis with nasal polyps in an Egyptian tertiary care hospital2026
  3. 3Endotypes of Chronic Rhinosinusitis with Primary and Recurring Nasal Polyps in the Latvian Population2024 · 2 citations
  4. 4Polyps’ Extension and Recurrence in Different Endotypes of Chronic Rhinosinusitis: A Series of 449 Consecutive Patients2024 · 12 citations
  5. 5Clinical Characteristics of Patients with Non-Type 2 Chronic Rhinosinusitis with Nasal Polyps2026 · 1 citations