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March 10, 2026

Clinical, laboratory, and histopathological factors associated with revision surgery in chronic rhinosinusitis with nasal polyps.

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Authors

AMAlex Iulian MileaITIonuţ TănaseAMAndreea Elena Milea

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Overview

Cross-sectional study investigates factors associated with revision surgery in chronic rhinosinusitis patients, suggesting inflammation's impact.

Key Points

  • This research aims to classify chronic rhinosinusitis patients based on inflammatory endotypes and assess the impact of eosinophilia on clinical outcomes.
  • Conducted a cross-sectional, observational study from January 2023 to December 2024
  • Enrolled 469 patients with chronic rhinosinusitis, including 239 with nasal polyps and 230 without
  • Analyzed blood and tissue eosinophilia levels to classify inflammatory endotypes and assess disease severity
  • Evaluated prevalence of asthma and NSAID allergies in both groups
  • Blood eosinophilia levels were higher in CRSwNP patients (17.4%) compared to CRSsNP (4.35%)
  • Tissue eosinophilia was present in 69.4% of CRSwNP patients versus 12.6% in CRSsNP
  • A strong association was found between tissue eosinophilia and the likelihood of requiring revision surgery
  • Moderate association observed with elevated blood eosinophil levels and revision surgery

Cite This Study

Milea et al. (2026) studied this question.

synapsesocial.com/papers/69af944f70916d39fea4b590https://doi.org/10.47162/rjme.66.4.07
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic Rhinosinusitis with Polyps and Comorbid Asthma: Results of Reslizumab Treatment2023 · 1 citations
  2. 2Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia1997 · 472 citations
  3. 3Histological and immunological features of non‐eosinophilic nasal polyps2007 · 168 citations
  4. 4Epidemiology and Economic Impact of Rhinosinusitis2004 · 382 citations
  5. 5Immunopathology of chronic rhinosinusitis2015 · 294 citations