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This review aims to explore the advancements in therapeutic hypothermia for stroke protection and its neuroprotective mechanisms.

EXPRESS: Therapeutic Hypothermia Via Hypothalamic Neuromodulation: A New Approach for Stroke Brain Protection

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Review summarizes therapeutic hypothermia approaches in stroke treatment, indicating potential for improved outcomes.

This review aims to explore the advancements in therapeutic hypothermia for stroke protection and its neuroprotective mechanisms.
Review of recent advances in therapeutic hypothermia research and mechanisms.
Discussion on traditional surface-cooling methods and the development of neuromodulation-based hypothermia.
Analysis of deep-brain stimulation effects on hypothalamic thermoregulation in stroke models.
Traditional therapeutic hypothermia (TH1.0) shows limited efficacy due to shivering and increased oxygen demand.
Neuromodulation-based hypothermia (TH2.0) offers a shivering-free alternative in mouse models.
TH2.0 demonstrates significant neuroprotective potential for improving stroke treatment, pending validation in non-human primates.

Zhang et al. (2026) studied this question.

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