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July 8, 2026PLoS ONEOpen Access

Longitudinal changes and risk factors of Opisthorchis viverrini infection after selective praziquantel treatment: evidence from urine antigen assay and fecal examination in an endemic community in Northeast Thailand

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Authors

KKKulthida Y. KopolratPBParichart BoueroyRKRatanee Kammoolkon

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Overview

Prospective study identifies high reinfection rates and behavioral risk factors in Northeast Thailand, suggesting urgent interventions.

Key Points

  • This study aims to explore the incidence and reinfection rates of Opisthorchis viverrini after praziquantel treatment and to identify associated risk factors.
  • Conducted a prospective study with a cohort of 612 participants in Northeast Thailand.
  • Monitored the status of opisthorchiasis using urine antigen assay and fecal examination techniques.
  • Measured incidence and reinfection rates post-treatment over a 24-week period.
  • Observed a baseline prevalence of 41.0% by urine antigen assay and 8.1% by fecal examination.
  • Calculated incidence of infection was 64.6/100 person-years, and reinfection rate after PZQ treatment was 63.7/100 person-years.
  • Identified significant risk factors: raw fish consumption (aRR = 7.52, p < 0.001) and frequent consumption (>10 times/month) (aRR = 3.60, p < 0.001).

Cite This Study

Kopolrat et al. (2026) studied this question.

synapsesocial.com/papers/6a4deabbd2ea289ef6284409https://doi.org/10.1371/journal.pone.0352854
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Re- Infection Rate of Opisthorchis Viverrini Five Years After Treatment with Praziquantel in High-Risk Area: A Community-Based Study2024
  2. 2Current Prevalence of Infection with Opisthorchis viverrini and Intestinal Parasites in Rural Communities in Northeast Thailand Using Stool Examinations and Serological Screening Methods2025 · 1 citations
  3. 3Impact of Community-Based Health Education and Sanitation Interventions on Opisthorchis viverrini Infection in an Endemic Area of Northeastern Thailand2026
  4. 4An explanatory sequential mixed methods study of Opisthorchis viverrini infection incidence and behavioral determinants over twenty years in rural Thailand2026
  5. 5Molecular evidence of a high prevalence of Opisthorchis viverrini infection in an endemic community in Sakon Nakhon Province, northeastern Thailand2026