What question did this study set out to answer?

Evaluate the feasibility and sensitivity of a multimodal home monitoring protocol for ALS.

Feasibility and sensitivity of a multimodal digital endpoint panel for amyotrophic lateral sclerosis: a prospective cohort study

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Prospective cohort study evaluates adherence to digital monitoring in ALS, indicating good feasibility and acceptability.

Evaluate the feasibility and sensitivity of a multimodal home monitoring protocol for ALS.
Conducted a 3-month prospective cohort study with 50 patients at University Medical Center Utrecht, Netherlands.
Monthly home assessments included spirometry, accelerometry, speech, and questionnaires on functioning.
Primary outcome was protocol adherence; secondary outcomes included acceptability and perceived burden.
Overall adherence was 83.2% (95% CI 76.9–88.6); no differences across modalities (p=0.75).
93.0% to 95.3% of patients found monthly remote assessments acceptable, with a mean burden score of 2.0.
Digital endpoints exhibited significant changes over 3 months (all p<0.05).

Botman et al. (2026) studied this question.

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