Key result
The risk of ischemic stroke was significantly higher in the first year after a diagnosis of Takotsubo cardiomyopathy compared to the second year (0.9% vs 0.4%, OR 2.6).
Why the study?
Takotsubo cardiomyopathy may be a risk factor for ischemic stroke, but the strength and temporal profile of this association remained uncertain.
Does Takotsubo cardiomyopathy increase the risk of ischemic stroke in the first year following diagnosis compared to the second year?
Cohort (n=5,283)
Yes
Does Takotsubo cardiomyopathy increase the risk of ischemic stroke in the first year following diagnosis compared to the second year?
Odds Ratio: 2.6 (95% CI 1.5–4.6)
Absolute Event Rate: 0.9% vs 0.4%
Takotsubo cardiomyopathy is associated with a small but significantly increased risk of ischemic stroke in the first year following diagnosis.
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May warrant closer first-year stroke surveillance after Takotsubo cardiomyopathy; leaves open causal confirmation and prevention trials.
Morris et al. (2020) conducted a cohort in Takotsubo cardiomyopathy (n=5,283). First year after Takotsubo cardiomyopathy diagnosis vs. Second year after Takotsubo cardiomyopathy diagnosis was evaluated on Ischemic stroke (OR 2.6, 95% CI 1.5-4.6). The risk of ischemic stroke was significantly higher in the first year after a diagnosis of Takotsubo cardiomyopathy compared to the second year (0.9% vs 0.4%, OR 2.6).
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