Key result
Higher TyG index linked to ~292% greater risk of lower extremity arterial disease in diabetes.
Why the study?
The triglyceride-glucose index is a marker of insulin resistance and predictor of atherosclerosis, but its relationship with lower extremity arterial disease risk in patients with diabetes required investigation.
Does the Triglyceride-Glucose (TyG) index predict lower extremity arterial disease in hospitalized patients with diabetes?
Observational (n=1,040)
No
Does the Triglyceride-Glucose (TyG) index predict lower extremity arterial disease in hospitalized patients with diabetes?
Odds Ratio: 3.92 (95% CI 2.92–5.26)
p-value: p=<0.001
The Triglyceride-Glucose index is a significant independent predictor of lower extremity arterial disease in hospitalized patients with diabetes, offering a simple and inexpensive screening tool.
BACKGROUND: The triglyceride-glucose (TyG) index is a new, simple, and inexpensive marker of insulin resistance that is becoming increasingly important as a promising predictor of diseases such as atherosclerosis. Atherosclerosis is the main cause of lower extremity arterial disease (LEAD). In this study, we investigated the relationship between TyG index values and LEAD risk in patients with diabetes. METHODS: Patients with diabetes hospitalized at the Endocrinology Department of our hospital from June 1, 2021, to May 31, 2022, were retrospectively included. Baseline data, biochemical indicators, and ankle-brachial index values were collected. Statistical methods were used to assess the relationship between TyG index values and the risk of LEAD. RESULTS: A total of 1,040 hospitalized patients with diabetes were included, they were divided into the LEAD group with 168 patients and the no LEAD group with 872 patients. TyG index values in the LEAD group were higher than those in the no LEAD group (9.94 ± 0.78 vs. 9.36 ± 0.70, P < 0.001). TyG index values were independently correlated with LEAD risk in patients with diabetes (odds ratio = 3.92, 95% confidence interval (CI): 2.92-5.26, P < 0.001) in multivariate logistic regression analysis after adjusting for different risk factors (all P < 0.05). The area under the receiver operating characteristic curve was 0.72 (95% CI: 0.68-0.76) when TyG index values were used to diagnose LEAD in patients with diabetes. When Youden's index reached the maximum value of 0.34, the optimal TyG index threshold for predicting the onset of diabetic LEAD was 9.56, sensitivity was 71.1%, and specificity was 63.0%. CONCLUSIONS: Increases in TyG index values were associated with the risk of LEAD in patients with diabetes and, thus, may be used as a predictor of LEAD in this patient population, especially in primary care institutions with relatively few resources.
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Ning et al. (2023) conducted an observational in Diabetes (n=1,040). Triglyceride-glucose (TyG) index vs. Lower TyG index values was evaluated on Lower extremity arterial disease (LEAD) (OR 3.92, 95% CI 2.92-5.26, p=<0.001). Higher triglyceride-glucose (TyG) index values were independently associated with an increased risk of lower extremity arterial disease in patients with diabetes (OR 3.92; 95% CI 2.92-5.26; P<0.001).
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