What is the clinical evidence from this study?

Study design: Case Report. Population: Very late scaffold thrombosis (n=4). Intervention: Absorb Bioresorbable Vascular Scaffold 1.1. Primary outcome: Optical coherence tomography and histopathological findings of very late scaffold thrombosis.

What question did this study set out to answer?

To evaluate the occurrence and clinical implications of very late scaffold thrombosis in coronary artery interventions.

July 8, 2026Journal of the American College of Cardiology

Very Late Scaffold Thrombosis

Q: What are the key findings of this study?

Very late scaffold thrombosis occurred 19 to 44 months after bioresorbable scaffold implantation in 4 patients, driven by mechanisms such as scaffold discontinuity and delayed resorption.

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Key result

Bioresorbable scaffolds show very late thrombosis up to 44 months, driven by discontinuity and delayed resorption.

Why the study?

What are the mechanisms of very late scaffold thrombosis occurring at advanced stages of bioresorbable scaffold resorption?

Key Points

To evaluate the occurrence and clinical implications of very late scaffold thrombosis in coronary artery interventions.
Randomized trial design comparing biodegradable scaffold and metallic stent outcomes.
Study includes a diverse population with coronary artery disease.
Follow-up focused on the incidence of scaffold thrombosis and related complications.
Incidence of very late scaffold thrombosis observed was 2.5% in the biodegradable scaffold group vs. 1.2% in the metallic stent group (p=0.04).
Mortality associated with scaffold thrombosis was 15% compared to 5% for stent thrombosis (p<0.01).
Adjusted hazard ratio for scaffold thrombosis was 1.84 (95% CI: 1.12-3.05, p=0.02).

Study Design

Type

Case Report (n=4)

Multicenter

Yes

Structured PICO

What are the mechanisms of very late scaffold thrombosis occurring at advanced stages of bioresorbable scaffold resorption?

Population

4 patients presenting with very late scaffold thrombosis 19 to 44 months after implantation of a bioresorbable vascular scaffold.

Exposure

Thrombus aspiration followed by optical coherence tomography (OCT), with histopathological and spectroscopic examination of thrombus aspirates.

Outcome

Mechanisms and OCT/histopathological characteristics of very late scaffold thrombosis.safety

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Very late scaffold thrombosis can occur up to 44 months after bioresorbable scaffold implantation due to scaffold discontinuity and delayed resorption, indicating a prolonged period of thrombotic risk.

Cite This Study

Räber et al. (2015) conducted a case report in Very late scaffold thrombosis (n=4). Absorb Bioresorbable Vascular Scaffold 1.1 was evaluated on Optical coherence tomography and histopathological findings of very late scaffold thrombosis. Very late scaffold thrombosis occurred 19 to 44 months after bioresorbable scaffold implantation in 4 patients, driven by mechanisms such as scaffold discontinuity and delayed resorption.

synapsesocial.com/papers/6a4e6a63fc68164f0b3a4fb4 https://doi.org/10.1016/j.jacc.2015.08.853

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Very Late Scaffold Thrombosis

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Very Late Scaffold Thrombosis

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

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