What is the clinical evidence from this study?

Population: Coronary artery disease. Intervention: HDL from patients with CAD vs. HDL from healthy subjects. Primary outcome: Endothelial cell apoptosis and activation of anti- and proapoptotic pathways.

What question did this study set out to answer?

This research examines the differences in endothelial pro- and antiapoptotic pathway activation by HDL from coronary artery disease patients versus healthy individuals.

July 8, 2026CirculationOpen Access

Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease

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Key result

CAD-derived HDL fails to protect against endothelial apoptosis and instead activates proapoptotic pathways.

Why the study?

Does HDL from patients with CAD differ from healthy HDL in its effects on endothelial apoptosis?

Key Points

This research examines the differences in endothelial pro- and antiapoptotic pathway activation by HDL from coronary artery disease patients versus healthy individuals.
HDL was isolated from patients with stable coronary artery disease and healthy subjects.
In vitro and in vivo experiments were conducted to assess endothelial cell apoptosis and protein expression changes.
Proteomics analyses were performed to characterize compositional differences in HDL.
HDL from healthy subjects activated endothelial antiapoptotic Bcl-xL and reduced apoptosis, while CAD HDL failed to do so.
CAD HDL promoted endothelial proapoptotic pathways, particularly activation of tBid, indicating a shift towards apoptosis.
Proteomic analysis revealed decreased clusterin and increased apolipoprotein C-III content in CAD HDL, contributing to its altered effects.

Structured PICO

Does HDL from patients with CAD differ from healthy HDL in its effects on endothelial apoptosis?

Population

Endothelial cells in vitro and apolipoprotein E-deficient mice in vivo; HDL isolated from patients with stable CAD, acute coronary syndrome, and healthy subjects

Exposure

Treatment with HDL from patients with stable CAD (HDL(sCAD)) or acute coronary syndrome (HDL(ACS))

Comparator

Treatment with HDL from healthy subjects (HDL(Healthy))

Outcome

Endothelial cell apoptosis and activation of anti- and proapoptotic pathways (Bcl-xL, tBid)surrogate

Discussion

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Implication

HDL from patients with coronary artery disease exhibits altered functional properties, stimulating rather than inhibiting endothelial apoptosis due to proteome remodeling.

Cite This Study

Riwanto et al. (2013) studied Coronary artery disease. HDL from patients with CAD vs. HDL from healthy subjects was evaluated on Endothelial cell apoptosis and activation of anti- and proapoptotic pathways. HDL from patients with coronary artery disease failed to inhibit endothelial apoptosis and instead stimulated proapoptotic pathways compared to HDL from healthy subjects.

synapsesocial.com/papers/6a4e6a6dfc68164f0b3a4fca https://doi.org/10.1161/circulationaha.112.108753

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Implication

HDL from patients with coronary artery disease exhibits altered functional properties, stimulating rather than inhibiting endothelial apoptosis due to proteome remodeling.

Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider