Key result
Ischemic stroke linked to increased peri-infarct expression of glial and inflammatory markers in humans.
Observational
Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after ischemic stroke, compared with adjacent normal tissues and control subjects. Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG, but showed no overlap with ED1-positive activated microglia. Our findings suggest that reactive gliosis and glial scar formation as seen in animal models of stroke are reflective of what occurs in the human brain after an ischemic injury.
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Huang et al. (2014) conducted an observational in Ischemic stroke. Ischemic stroke vs. Adjacent normal tissues and control subjects was evaluated on Expression of GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG). Ischemic stroke in humans was associated with significantly increased GFAP, ED1, and CSPG expression in cortical peri-infarct regions compared with adjacent normal tissues and controls.
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