What does this research mean for the field?

Primary Raynaud's syndrome is associated with a significantly increased risk of venous thromboembolism, including deep vein thrombosis and pulmonary embolism, independent of major confounding conditions. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess whether presumed primary Raynaud's syndrome is independently associated with an increased risk of incident venous thromboembolism.

September 6, 2026International Journal of Medical SciencesOpen Access

Risk of Venous Thromboembolism in Patients with Presumed Primary Raynaud's Syndrome: A Propensity-Matched Study Using the TriNetX Database

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Authors

SHShang-Hsuan Huang CYChao‐Bin Yeh YWYu‐Hsun Wang

Discussion

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Overview

Retrospective cohort study finds increased venous thromboembolism risk in presumed primary Raynaud's syndrome, indicating potential systemic vascular dysfunction beyond localized vasospasm.

Key Points

To assess whether presumed primary Raynaud's syndrome is independently associated with an increased risk of incident venous thromboembolism.
Conducted a retrospective cohort study using electronic health record data from the TriNetX global database between 2015 and 2024.
Performed 1:1 propensity score matching to balance 93,263 patients with Raynaud's syndrome and 93,263 controls across demographics, comorbidities, healthcare utilization, and laboratory parameters.
Excluded patients with autoimmune disorders, malignancy, vascular disease, thrombophilia, pregnancy, or exposure to anticoagulants and hormonal contraceptives to minimize confounding.
Incident venous thromboembolism developed in 1,407 patients with Raynaud's syndrome compared with 1,179 controls (HR 1.33; 95% CI 1.24–1.44).
Significantly elevated risks were observed for both deep vein thrombosis (HR 1.30; 95% CI 1.18–1.43) and pulmonary embolism (HR 1.38; 95% CI 1.24–1.54).
Subgroup analyses revealed a stronger association in younger individuals, with consistent risk profiles across sexes.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1df228139818eab20b99 https://doi.org/10.7150/ijms.139691

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September 6, 2026International Journal of Medical SciencesOpen Access

Risk of Venous Thromboembolism in Patients with Presumed Primary Raynaud's Syndrome: A Propensity-Matched Study Using the TriNetX Database

View Full Paper

Ask AI

Bookmark

Authors

SHShang-Hsuan Huang CYChao‐Bin Yeh YWYu‐Hsun Wang

Discussion

Member takes

Overview

Retrospective cohort study finds increased venous thromboembolism risk in presumed primary Raynaud's syndrome, indicating potential systemic vascular dysfunction beyond localized vasospasm.

Key Points

To assess whether presumed primary Raynaud's syndrome is independently associated with an increased risk of incident venous thromboembolism.
Conducted a retrospective cohort study using electronic health record data from the TriNetX global database between 2015 and 2024.
Performed 1:1 propensity score matching to balance 93,263 patients with Raynaud's syndrome and 93,263 controls across demographics, comorbidities, healthcare utilization, and laboratory parameters.
Excluded patients with autoimmune disorders, malignancy, vascular disease, thrombophilia, pregnancy, or exposure to anticoagulants and hormonal contraceptives to minimize confounding.
Incident venous thromboembolism developed in 1,407 patients with Raynaud's syndrome compared with 1,179 controls (HR 1.33; 95% CI 1.24–1.44).
Significantly elevated risks were observed for both deep vein thrombosis (HR 1.30; 95% CI 1.18–1.43) and pulmonary embolism (HR 1.38; 95% CI 1.24–1.54).
Subgroup analyses revealed a stronger association in younger individuals, with consistent risk profiles across sexes.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1df228139818eab20b99 https://doi.org/10.7150/ijms.139691

View Full Paper

Ask AI

Bookmark