Key result
Defective regulation of the ryanodine receptor through structural intra- and inter-subunit interactions leads to neuromuscular disorders and arrhythmogenic cardiac disease.
Design
Review
Structural insights into ryanodine receptor regulation may guide future therapies for muscle disorders; leaves open prospective clinical validation.
The ryanodine receptor/Ca2+ release channel plays a pivotal role in skeletal and cardiac muscle excitation-contraction coupling. Defective regulation leads to neuromuscular disorders and arrhythmogenic cardiac disease. This mini-review focuses on channel regulation through structural intra- and inter-subunit interactions and their implications in ryanodine receptor pathophysiology.
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Seidel et al. (2015) studied this question. Defective regulation of the ryanodine receptor through structural intra- and inter-subunit interactions leads to neuromuscular disorders and arrhythmogenic cardiac disease.
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