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December 1, 2002Cardiovascular Research

The cardiac ryanodine receptor (calcium release channel) Emerging role in heart failure and arrhythmia pathogenesis

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Authors

MSMark ScooteEast Suffolk and North Essex NHS Foundation Trust

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Implication

Positions RyR2 as therapeutic target in HF and inherited arrhythmias; leaves open whether modulation improves patient outcomes.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Mark Scoote (2002) studied this question.

synapsesocial.com/papers/6a21536d6edeeecbd302f641 https://doi.org/10.1016/s0008-6363(02)00574-6

Topics

Heart failure HFrEF treatment

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effect of Ryanodine on Sarcoplasmic Reticulum Ca<sup>2+</sup>Accumulation in Nonfailing and Failing Human Myocardium1995 · 38 citations
2Enhanced Basal Activity of a Cardiac Ca <sup>2+</sup> Release Channel (Ryanodine Receptor) Mutant Associated With Ventricular Tachycardia and Sudden Death2002 · 184 citations
3No Role for the Ryanodine Receptor in Regulating Cardiac Contraction?2000 · 30 citations
4Altered Stoichiometry of FKBP12.6 Versus Ryanodine Receptor as a Cause of Abnormal Ca <sup>2+</sup> Leak Through Ryanodine Receptor in Heart Failure2000 · 225 citations
5Ryanodine receptor mutations in malignant hyperthermia and central core disease2000 · 345 citations