Key result
RyR2 macromolecular complex modulates channel function in response to sympathetic activation.
Design
Review
Authors
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May inform RyR2-targeted therapies in sympathetic-driven arrhythmias; leaves open clinical translation pending prospective trials.
This paper reviews the cardiac ryanodine receptor (RyR2) macromolecular complex and its role in excitation-contraction coupling and sympathetic nervous system response.
Andrew R. Marks (2002) conducted a review in Sudden Cardiac Death. Cardiac Ryanodine Receptor/Calcium Release Channel Mutations was evaluated. The cardiac ryanodine receptor (RyR2) macromolecular complex plays a key role in modulating channel function in response to sympathetic nervous system activation.
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