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Catalytic regioselective hydrocarbofunctionalization enhances functionalization of alkenes using anthrones and 9-phenanthrols, suggesting a versatile approach.
Anthrones and 9-phenanthrols are common polycyclic aromatic hydrocarbon substructures in many natural products and pharmaceutical chemicals. Herein, we present a palladium-catalyzed regioselective hydrocarbofunctionalization of unactivated alkenes with anthrones and 9-phenanthrols. 8-Aminoquinoline is employed as a cleavable bidentate directing group to control regioselectivity. The strategy is amenable to a broad range of substrates, providing densely functionalized anthrone and 9-phenanthrol derivatives generally in good yields.
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Zhifeng Mao (2026) studied this question.
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