Key result
18F-FAPI-04 PET/CT shows higher uptake and better lesion detectability than 18F-FDG for marginal zone lymphoma.
Why the study?
Marginal zone lymphoma involving multiple muscles and subcutaneous adipose tissue is extremely rare.
Does 18F-FAPI-04 PET/CT improve lesion detectability compared to 18F-FDG PET/CT in marginal zone lymphoma with muscle and subcutaneous involvement?
Case Report (n=1)
Does 18F-FAPI-04 PET/CT improve lesion detectability compared to 18F-FDG PET/CT in marginal zone lymphoma with muscle and subcutaneous involvement?
18F-FAPI-04 PET/CT may be superior to 18F-FDG PET/CT for detecting muscle and subcutaneous adipose tissue involvement in marginal zone lymphoma.
May enhance MZL lesion detection over FDG; hypothesis-generating for FAPI PET/CT in lymphoma staging.
Marginal zone lymphoma (MZL) involving multiple muscles and subcutaneous adipose tissue is extremely rare. We present PET/CT findings of pathologically confirmed MZL with muscle and subcutaneous involvement in a 63-year-old man. 18F-FAPI-04 PET/CT demonstrated significantly higher radiotracer uptake and better lesion detectability than 18F-FDG PET/CT in all detectable lesions and, in addition, identified occult right neck muscle involvement not clearly appreciable on 18F-FDG PET/CT. This case highlights the superiority of 18F-FAPI-04 PET/CT over 18F-FDG PET/CT for evaluating MZL with muscle and subcutaneous adipose tissue involvement, especially for mildly FDG-avid lesions.
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Feng et al. (2026) conducted a case report in Marginal zone lymphoma with muscle and subcutaneous involvement (n=1). 18F-FAPI-04 PET/CT vs. 18F-FDG PET/CT was evaluated on Lesion detectability and radiotracer uptake. 18F-FAPI-04 PET/CT demonstrated significantly higher radiotracer uptake and better lesion detectability than 18F-FDG PET/CT for evaluating marginal zone lymphoma.
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