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July 9, 2026The Journal of Basic and Applied ZoologyOpen Access

Casein protein from Gir and Jersey cow milk: biochemical profiling, MALDI-TOF/MS peptide fingerprinting, and cytotoxic effects on HT-29 cells

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Authors

SSS SivaranjaniVRVeerapandiyan RamabhaiASArumugam Sarumathi

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Overview

Randomized trial compares casein properties and cytotoxicity on colorectal cancer cells from two cow breeds, suggesting potential therapeutic uses.

Key Points

  • The aim is to compare the casein characteristics and their anticancer effects from Gir and Jersey cows.
  • Compared protein, carbohydrate, and fat contents in Gir and Jersey milk.
  • Evaluated cytotoxicity on HT-29 and biocompatibility with Vero cells via dose-response assays.
  • Analyzed casein profiles using native-PAGE, SDS-PAGE, and MALDI-TOF/MS.
  • Gir milk had higher protein (10.7 mg/mL) and carbohydrate (2.4 mg/mL) contents than Jersey milk (1.6 mg/mL).
  • HT-29 cells showed 67.50% cytotoxicity for Gir casein and 75.80% for Jersey casein at 50 µg/mL.
  • Jersey casein resulted in approximately 93.8% loss of viability in Vero cells.

Cite This Study

Sivaranjani et al. (2026) studied this question.

synapsesocial.com/papers/6a4f3c8a2b81a944af575c91https://doi.org/10.1186/s41936-026-00613-2
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