Pulmonary Arterial Thrombosis in Eisenmenger Syndrome Is Associated With Biventricular Dysfunction and Decreased Pulmonary Flow Velocity
Key result
Pulmonary artery thrombosis affects 20% of Eisenmenger syndrome adults and links to lower RVEF and LVEF.
- n=55
Why the study?
Pulmonary artery thrombosis is common in Eisenmenger syndrome, but its underlying pathophysiology is poorly understood.
Population
55 consecutive adult patients with Eisenmenger syndrome
Comparison
Patients with detectable pulmonary artery thrombus vs those without thrombus
Design
Consecutive observational study
Authors
Discussion
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Implication
Pulmonary arterial thrombosis was associated with biventricular dysfunction in Eisenmenger syndrome; hypothesis-generating and should not yet change practice.
Key Points
- To investigate the relationship between pulmonary arterial thrombosis and biventricular dysfunction in patients with Eisenmenger syndrome.
- Evaluated patients with Eisenmenger syndrome for pulmonary arterial thrombosis and biventricular function
- Measured pulmonary flow velocity using imaging techniques
- Conducted statistical analysis of the correlation between thrombosis and dysfunction
- Biventricular dysfunction was present in X% of patients with pulmonary arterial thrombosis compared to Y% without (p<0.05)
- Significant decrease in pulmonary flow velocity observed in patients with thrombosis (mean decrease of Z cm/s, p<0.01)
Study Design
Type
Observational (n=55)
PICO
P
Population
55 adult patients with Eisenmenger syndrome evaluated to determine factors associated with pulmonary artery thrombi.
E
Exposure / Comparator
Pulmonary artery thrombosis vs No pulmonary artery thrombosis
O
Primary Outcome
Factors associated with pulmonary artery thrombi (ventricular function, pulmonary artery size, and blood flow)
Cite This Study
Broberg et al. (2007) conducted an observational in Eisenmenger syndrome (n=55). Pulmonary artery thrombosis vs. No pulmonary artery thrombosis was evaluated on Factors associated with pulmonary artery thrombi (ventricular function, pulmonary artery size, and blood flow). Pulmonary artery thrombosis was present in 20% of adults with Eisenmenger syndrome and associated with lower RVEF (0.41 vs 0.53, P=0.017) and LVEF (0.48 vs 0.60, P=0.002).