Key result
A 6-month exercise and caloric restriction intervention significantly increased VO2max in metabolic syndrome, while resting and stress cardiac function remained unchanged.
Why the study?
Does exercise and caloric restriction improve exercise capacity and diastolic dysfunction in patients with Metabolic syndrome?
Does exercise and caloric restriction improve exercise capacity and diastolic dysfunction in patients with Metabolic syndrome?
In early metabolic syndrome, exercise intolerance is likely due to general deconditioning rather than cardiac dysfunction, as lifestyle interventions improve exercise capacity without changing cardiac function.
Answers are grounded in this paper and cite their sources.
May support lifestyle weight loss to improve exercise capacity in metabolic syndrome; leaves open effects on clinical outcomes.
Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO(2max) five days/week (approximately -375 kcal/session) and caloric restriction (approximately -600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 +/- 1y, women = 6, BMI = 33.5 +/- 1.0 kg/m(2)) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO(2max), resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 +/- 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO(2max) increases significantly with lifestyle while cardiac function remains unchanged.
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Chockalingam et al. (2010) studied Metabolic syndrome (n=18). Exercise and caloric restriction vs. Baseline was evaluated on Exercise capacity (VO2max) and diastolic dysfunction (E/E'). A 6-month exercise and caloric restriction intervention significantly increased VO2max in metabolic syndrome, while resting and stress cardiac function remained unchanged.
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