Key result
Vasodilatory pharmacologic SPECT stress testing can produce false positive septal/anteroseptal perfusion defects in patients with a left bundle branch block.
Why the study?
False-positive results are more commonly seen with exercise stress testing, but can also occur with pharmacologic stress testing in the setting of left bundle branch block.
Case Report (n=1)
Pharmacologic SPECT stress testing can yield false positive septal/anteroseptal perfusion defects in patients with LBBB, suggesting PET may be more reliable.
False-positive septal defects can occur on pharmacologic SPECT in LBBB; leaves open whether PET is preferable in this population.
We herein report a case of a false positive vasodilatory pharmacologic SPECT stress test in the setting of a left bundle branch block (LBBB). While this is more commonly seen with exercise stress testing, it can also occur with pharmacologic stress testing. In our SPECT exam, we illustrate the commonly mistaken septal/anteroseptal perfusion defects in those patients with a LBBB. PET stress testing may be more reliable for patients with LBBB.
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Nguyen et al. (2021) conducted a case report in Left bundle branch block (LBBB) (n=1). Vasodilatory pharmacologic SPECT stress test was evaluated on False positive septal/anteroseptal perfusion defects. Vasodilatory pharmacologic SPECT stress testing can produce false positive septal/anteroseptal perfusion defects in patients with a left bundle branch block.
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