Key result
Cigarette smoking alters endothelial function by a direct toxic effect, triggering haemostatic activation and changes in platelet physiology that contribute to the development of atherothrombosis.
Why the study?
How does cigarette smoking contribute to the development of atherothrombosis through endothelial-haemostatic dysfunction?
Design
Review
Authors
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Emphasizes smoking cessation in vascular prevention; leaves open targeted endothelial therapies pending clinical trials.
How does cigarette smoking contribute to the development of atherothrombosis through endothelial-haemostatic dysfunction?
This review highlights the pathophysiological mechanisms by which cigarette smoking induces endothelial dysfunction and subsequent atherothrombosis.
Cacciola et al. (2007) conducted a review in Atherothrombosis. Cigarette smoking was evaluated. Cigarette smoking alters endothelial function by a direct toxic effect, triggering haemostatic activation and changes in platelet physiology that contribute to the development of atherothrombosis.
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