Key result
Overweight status is linked to depressed LV-GLS and increased fQRS-T angle, indicating subclinical myocardial dysfunction.
Why the study?
Studies assessing the myocardial involvement described in obesity cardiomyopathy among overweight subjects were lacking prior to the development of overt obesity cardiomyopathy.
Does overweight status associate with subclinical left ventricular electrical and mechanical dysfunction compared to normal weight?
Observational (n=160)
Does overweight status associate with subclinical left ventricular electrical and mechanical dysfunction compared to normal weight?
Absolute Event Rate: -14.5% vs -21.7%
p-value: p=< .001
Overweight individuals exhibit subclinical left ventricular mechanical and electrical dysfunction compared to normal-weight individuals, detectable by 3D-speckle tracking echocardiography and fQRS-T angle.
May indicate early myocardial changes in overweight; leaves open whether screening or intervention alters progression to cardiomyopathy.
BACKGROUND: Overweightness is a considerable step in the process leading to obesity. There are no sufficient studies on the effect of cardiomyopathy defined in obese patients about overweight subjects. We thought that it may be useful to examine the myocardial involvement in overweight individuals electro-mechanically with more sensitive techniques before the development of obesity cardiomyopathy. AIM: The aim of the present study was to demonstrate whether or not there are subclinical left ventricular (LV) electrical and mechanical dysfunctions in overweight patients using frontal QRS-T (fQRS-T) angle (electrically) and 3D-speckle tracking echocardiography (mechanically). METHODS: A total of 80 overweight patients and 80 age- and sex-matched normal weight individuals were enrolled into the study. 3D-STE examinations of the patients were performed. Electrocardiographic recordings were obtained for fQRS-T angle assessment. RESULTS: The LV-GLS and LV-GCS were significantly depressed in the overweight group than in the normal weight group (-14.5 ± 3.4 vs. -21.7 ± 3.6, p < .001; -15.2 ± 4.6 vs. -24.3 ± 4.8, p < .001, respectively). The fQRS-T angle was found to be increased in the overweight group (142.5 ± 39.2 vs. 114.7 ± 43.5, p = < .001). Statistically significant positive linear correlations were observed between BMI with LV-GLS, LV-GCS, and fQRS-T angle. LV-GLS and LV-GCS were found to be disrupted linearly as BMI increased (r = .718 for BMI and LV-GLS, r = .653 for BMI and LV-GCS). As BMI increased, it was found that the fQRS-T angle increased (r = .692 for BMI and fQRS-T angle). CONCLUSION: Our results support that, overweight individuals, despite their being apparently healthy, may have subclinical LV myocardial mechanical and electrical dysfunction.
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Mammadov et al. (2023) conducted an observational in Overweight (n=160). Overweight vs. Normal weight was evaluated on Left ventricular global longitudinal strain (LV-GLS) (p=< .001). Overweight individuals had significantly depressed LV-GLS (-14.5 vs -21.7, p<0.001) and increased fQRS-T angle compared to normal weight controls, indicating subclinical myocardial dysfunction.
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