Key result
Overweight linked to reduced left ventricular GLS versus normal weight in patients with preserved EF.
Why the study?
Little remains known about the role of overweight in promoting progressive atrial and ventricular myocardial dysfunction in patients with preserved ejection fraction.
Does overweight reduce left ventricular and atrial function in patients with preserved ejection fraction at low-to-moderate cardiovascular risk?
Observational (n=70)
Does overweight reduce left ventricular and atrial function in patients with preserved ejection fraction at low-to-moderate cardiovascular risk?
Absolute Event Rate: -17.2% vs -18.7%
p-value: p=< 0.05
Overweight is associated with early subclinical reduction in global left ventricular longitudinal function in patients with preserved ejection fraction and low-to-moderate cardiovascular risk.
Supports subclinical LV strain reduction in overweight patients with preserved EF; hypothesis-generating, needs prospective confirmation before clinical adoption.
BACKGROUND: Little remains known about the role of overweight to promote progressive atrial and ventricular myocardial dysfunction. Aim of this study was to investigate the potential influence of overweight on left ventricular (LV) and atrial (LA) function, as assessed by speckle tracking strain analysis, in patients at low-to-moderate global cardiovascular risk. METHODS: Seventy patients presenting 1 or more cardiovascular risk factor, with preserved ejection fraction, were enrolled. Peak atrial longitudinal strain (PALS) and Peak ventricular longitudinal strain (PVLS) were calculated by averaging values observed in all LV or LA segments, in four- and two-chamber views (global PALS and global PVLS), using a commercially available semiautomated two-dimensional (2D) strain software. RESULTS: Global PALS was similar in the 2 groups, while global PVLS was significantly lower in the overweight group as compared to normal weight (-17.2 ± 3.3 vs. -18.7 ± 2.8, P < 0.05). Univariate analysis of correlation showed a significantly correlation between global PALS and PVLS (r = -0.43, P < 0.01), as well as with E/A ratio (r = 0.40, P < 0.01) and with LV mass index (r = -0.34, P < 0.05). In multivariate linear regression analysis, these parameters were confirmed as independent predictors of PALS. CONCLUSION: In subjects at low-to-moderate cardiovascular risk, overweight is a key determinant of the reduction of global LV longitudinal function as assessed by 2D strain.
No takes yet. Share an insight, caveat, or question.
Caputo et al. (2013) conducted an observational in Low-to-moderate global cardiovascular risk with preserved ejection fraction (n=70). Overweight vs. Normal weight was evaluated on Global peak ventricular longitudinal strain (PVLS) (p=< 0.05). Overweight was associated with significantly reduced global left ventricular longitudinal strain compared to normal weight (-17.2 vs. -18.7, P<0.05) in patients with preserved ejection fraction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: