Key result
A nonlinear feedback model accounted for sustained stable blood pressure oscillations of 0.1 to 0.4 Hz across species, with frequency variations primarily due to scaling of conduction times.
Population
Conscious rabbits under resting conditions (with references to rats and humans)
Comparison
Nonlinear feedback model containing an… vs Linear feedback model
Design
Preclinical
Authors
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Caution advised before clinical translation; leaves open human validation of nonlinear BP oscillation models.
A nonlinear feedback model better explains the stable slow oscillations in blood pressure across species compared to linear models, localizing the nonlinearity to the central nervous system.
Ringwood et al. (2001) studied Blood pressure oscillations. Nonlinear feedback model vs. Linear feedback model was evaluated on Sustained stable oscillations in blood pressure. A nonlinear feedback model accounted for sustained stable blood pressure oscillations of 0.1 to 0.4 Hz across species, with frequency variations primarily due to scaling of conduction times.
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