Key result
In a swine model of left ventricular hypertrophy, ETB receptor density was significantly decreased compared to controls (4.588 vs 6.435; P<0.001).
Why the study?
Does left ventricular hypertrophy alter endothelin receptor subtypes and COX-derived products in porcine epicardial coronary arteries?
Population
Swine model of left ventricular hypertrophy (LVH) occurring 2 months after aortic banding, and control group
Comparison
Evaluation of vascular reactivity to ET-1… vs Control swine without aortic banding
Design
Preclinical
Follow-up
2 months (duration of aortic banding)
Authors
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Potential ET/COX targets for LVH coronary dysfunction identified in swine model; hypothesis-generating and requires clinical validation before practice change.
Does left ventricular hypertrophy alter endothelin receptor subtypes and COX-derived products in porcine epicardial coronary arteries?
Absolute Event Rate: 4.588% vs 6.435%
p-value: p=< 0.001
In a swine model of LVH, coronary endothelial dysfunction involves decreased ETB receptor density and increased COX-derived contracting factors, suggesting ETA receptor antagonists may improve endothelial function.
Desjardins et al. (2005) studied Left ventricular hypertrophy. Left ventricular hypertrophy (aortic banding) vs. Control was evaluated on ETB receptor density (p=< 0.001). In a swine model of left ventricular hypertrophy, ETB receptor density was significantly decreased compared to controls (4.588 vs 6.435; P<0.001).
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