Key result
Tissue-specific enhancement of ET-1 expression was observed in L-NAME-treated SHR and renovascular hypertensive rats compared to controls, but not in spontaneously hypertensive rats.
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Findings from rat models suggest ET-1 involvement may vary by hypertension etiology; leaves open human relevance and targeted therapies.
Deng et al. (1998) studied Hypertension. Hypertensive rat models (L-NAME-treated SHR, 2-K 1C, 1-K 1C) vs. Wistar-Kyoto (WKY) rats and unilaterally nephrectomized control rats was evaluated on preproET-1 mRNA abundance in blood vessels, heart, and kidneys. Tissue-specific enhancement of ET-1 expression was observed in L-NAME-treated SHR and renovascular hypertensive rats compared to controls, but not in spontaneously hypertensive rats.
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