Why the study?
Does ETA-selective receptor antagonist A-127722.5 improve blood pressure and vascular structure/function in stroke-prone spontaneously hypertensive rats?
Does ETA-selective receptor antagonist A-127722.5 improve blood pressure and vascular structure/function in stroke-prone spontaneously hypertensive rats?
ETA receptor antagonism provides modest reductions in blood pressure and improvements in vascular structure and endothelial function in stroke-prone spontaneously hypertensive rats.
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ETA antagonism shows vascular benefits in hypertensive rats; leaves open translation to human therapy.
Sharifi et al. (1998) studied this question.
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