Why the study?
Does quinapril reduce ET-1 expression and improve renal lesions in uninephrectomized spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) uninephrectomized at 20 weeks of age (UNX-SHR)
Comparison
ACE inhibitor quinapril administered from the… vs Untreated UNX-SHR, age-matched SHR, and…
Design
Preclinical
Follow-up
25 weeks (from 20 to 45 weeks of age)
Authors
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Supports ET-1 mediation of ACE-inhibitor renoprotection in rats; hypothesis-generating, should not change clinical practice.
Does quinapril reduce ET-1 expression and improve renal lesions in uninephrectomized spontaneously hypertensive rats?
In a rat model of hypertension and renal injury, ACE inhibition with quinapril reduced ET-1 expression, suggesting its beneficial effects may be partly mediated by decreasing ET-1 generation.
Largo et al. (1997) studied this question.
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