Key result
MitraClip implantation significantly reduced the incidence of severe mitral regurgitation at follow-up to 0% compared to 94.7% with conservative therapy in high-risk patients.
Why the study?
Does MitraClip implantation improve clinical outcomes, echocardiographic parameters, and quality of life in patients with severe secondary MR disqualified from surgery compared to conservative therapy?
Cohort (n=33)
No
Does MitraClip implantation improve clinical outcomes, echocardiographic parameters, and quality of life in patients with severe secondary MR disqualified from surgery compared to conservative therapy?
Absolute Event Rate: 0% vs 94.7%
p-value: p=<0.001
MitraClip implantation improves symptoms, MR severity, and quality of life compared to conservative management in patients with severe secondary MR who are ineligible for surgery.
Should not change practice in inoperable secondary MR; leaves open comparative effectiveness versus conservative therapy.
INTRODUCTION: The most common alternative method of treatment for patients with severe mitral regurgitation (MR) is the implantation of a MitraClip device. AIM: To evaluate clinical and echocardiographic outcomes and quality of life (QoL) in patients with severe secondary MR, disqualified from surgical intervention, treated by implantation of a MitraClip in comparison to conservative therapy. MATERIAL AND METHODS: = 23). Clinical, echocardiographic, and QoL (EQ-5D-3L, SF-12v2 Health Survey) characteristics were compared at baseline and at follow-up of 8.0 ±2.3 months. RESULTS: = 0.01). CONCLUSIONS: Patients with severe secondary MR treated with the MitraClip achieved a significant reduction in symptoms and MR grade, as well as an improvement in QoL, as compared to patients treated conservatively.
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Krawczyk‐Ożóg et al. (2018) conducted a cohort in Severe secondary mitral regurgitation (n=33). MitraClip implantation vs. Conservative treatment was evaluated on Severe mitral regurgitation at follow-up (p=<0.001). MitraClip implantation significantly reduced the incidence of severe mitral regurgitation at follow-up to 0% compared to 94.7% with conservative therapy in high-risk patients.
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