Key result
Percutaneous mitral annuloplasty using a coronary sinus device reduced mitral regurgitation from 3-4+ to 0-1+ (P<0.03) and decreased septal-lateral annular diameter in an ovine model.
Why the study?
Does a percutaneous transvenous coronary sinus annuloplasty device reduce mitral regurgitation in an ovine model of acute ischemic MR?
Does a percutaneous transvenous coronary sinus annuloplasty device reduce mitral regurgitation in an ovine model of acute ischemic MR?
p-value: p=< 0.03
Percutaneous transvenous coronary sinus annuloplasty is feasible and acutely reduces ischemic mitral regurgitation in an ovine model.
Hypothesis-generating for transvenous mitral annuloplasty; prospective human studies required before clinical consideration.
Annuloplasty is the cornerstone of surgical mitral valve repair. A percutaneous transvenous catheter-based approach for mitral valve repair was tested by placing a novel annuloplasty device in the coronary sinus of sheep with acute ischemic mitral regurgitation. Mitral regurgitation was reduced from 3-4+ to 0-1+ in all animals (P < 0.03). The annuloplasty functioned by reducing septal-lateral mitral annular diameter (30 +/- 2.1 mm preinsertion vs. 24 +/- 1.7 mm postinsertion; P < 0.03). These preliminary experiments demonstrate that percutaneous mitral annuloplasty is feasible. Further study is necessary to demonstrate long-term safety and efficacy of this novel approach.
No takes yet. Share an insight, caveat, or question.
Liddicoat et al. (2003) studied Acute ischemic mitral regurgitation. Percutaneous transvenous catheter-based annuloplasty device vs. Pre-insertion (baseline) was evaluated on Mitral regurgitation severity and septal-lateral mitral annular diameter (p=< 0.03). Percutaneous mitral annuloplasty using a coronary sinus device reduced mitral regurgitation from 3-4+ to 0-1+ (P<0.03) and decreased septal-lateral annular diameter in an ovine model.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: