Population
6 Dorsett hybrid sheep
Comparison
Occlusion of specific circumflex coronary… vs Baseline (before infarction)
Design
Preclinical
Authors
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Geometric changes may drive post-infarct ischemic MR; leaves open translation to human mechanisms or interventions.
Small geometric deformations, including asymmetric annular dilatation and papillary muscle displacement, are sufficient to cause moderate to severe acute ischemic mitral regurgitation after large posterior infarctions.
Gorman et al. (1997) studied this question.
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