Key result
Only combined posterior papillary muscle infarction and LV dilatation produce ischemic mitral regurgitation after MI.
Why the study?
The pathogenesis of ischemic mitral regurgitation after moderate-sized inferior myocardial infarction, specifically the roles of posterior papillary muscle infarction and left ventricular dilatation, was unclear.
Does the combination of posterior papillary muscle infarction and left ventricular dilatation cause ischemic mitral regurgitation after acute inferior myocardial infarction in a sheep model?
Design
Preclinical animal study
Follow-up
8 weeks
Authors
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This sheep model may clarify ischemic MR mechanisms; leaves open translation to human therapy.
Does the combination of posterior papillary muscle infarction and left ventricular dilatation cause ischemic mitral regurgitation after acute inferior myocardial infarction in a sheep model?
In a sheep model, the combination of posterior papillary muscle infarction and left ventricular dilatation is required to produce ischemic mitral regurgitation after moderate-sized inferior wall infarction.
Llaneras et al. (1993) studied Ischemic mitral insufficiency (n=25). Ligation of the second and third circumflex marginal arteries (infarcting posterior papillary muscle and LV mass) vs. Ligation of the first two circumflex marginal coronary arteries (infarcting LV mass without papillary muscle) was evaluated on Development of ischemic mitral regurgitation. The combination of posterior papillary muscle infarction and left ventricular dilatation, but neither alone, produced ischemic mitral regurgitation after moderate-sized inferior wall infarction.
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