Key result
Anterior MIs involving the papillary muscle in sheep fail to produce MR, unlike posterior infarctions.
Population
Sheep model
Comparison
Infarction of 24% and 33% of the anterior left… vs Previous data from large and small posterior…
Design
Preclinical
Follow-up
8 weeks
Authors
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Anterior papillary muscle infarction may not cause mitral regurgitation; leaves open infarct location effects on ischemic MR and requires human validation.
In a sheep model, anterior myocardial infarctions involving the anterior papillary muscle do not cause mitral regurgitation despite left ventricular dilatation, contrasting with the effects of posterior infarctions.
Gorman et al. (1998) studied Myocardial infarction (n=75). Anterior myocardial infarction (ligation of diagonal arteries) vs. Posterior left ventricular infarctions (historical data) was evaluated on Development of acute or chronic mitral regurgitation. Small and large anterior myocardial infarctions involving the anterior papillary muscle in sheep did not produce acute or chronic mitral regurgitation (0%), unlike posterior infarctions.
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