Key result
Pulmonary vein isolation for atrial fibrillation led to transient reductions in pulse interval variability and baroreflex sensitivity at 1 month, which were associated with freedom from recurrence.
Why the study?
Does pulmonary vein isolation alter cardiac autonomic modulation, and are these changes associated with atrial fibrillation recurrence in patients with atrial fibrillation?
Population
20 patients with AF referred for PVI
Comparison
Pre-PVI vs 1 and 6 months post-PVI
Design
Prospective cohort study
Follow-up
6 months
Authors
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PVI-related autonomic shifts may signal higher AF recurrence risk; leaves open whether modulation improves outcomes.
Cohort (n=20)
Does pulmonary vein isolation alter cardiac autonomic modulation, and are these changes associated with atrial fibrillation recurrence in patients with atrial fibrillation?
Successful pulmonary vein isolation induces transient parasympathetic denervation, which appears to be associated with efficacy in preventing atrial fibrillation recurrence.
Styczkiewicz et al. (2019) conducted a cohort in Atrial fibrillation (n=20). Pulmonary vein isolation (PVI) was evaluated on Cardiac autonomic modulation and atrial fibrillation recurrence. Pulmonary vein isolation for atrial fibrillation led to transient reductions in pulse interval variability and baroreflex sensitivity at 1 month, which were associated with freedom from recurrence.
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