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July 10, 2026NeurophotonicsOpen Access

Intraoperative tracking of tissue perfusion during cerebral aneurysm surgery with laser speckle contrast imaging: insights beyond standard intraoperative neuromonitoring for detecting ischemia

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Authors

EMEbenezer Raj Selvaraj MercyshalinieAKAbdurrahman F. KharbatMMMichael Machiorlatti

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Overview

Randomized trial demonstrates continuous tissue perfusion tracking in aneurysm surgery, implying enhanced ischemia detection.

Key Points

  • To evaluate the effectiveness of laser speckle contrast imaging (LSCI) for real-time monitoring of cerebral blood flow (CBF) during aneurysm surgery.
  • Case study of a 67-year-old female undergoing craniotomy for cerebral aneurysm.
  • Used LSCI for continuous cortical perfusion monitoring compared to IONM alerts and ICGA.
  • Statistical analysis through paired t-test, mixed effects model, and changepoint analysis across seven ROIs.
  • LSCI detected significant decreases in cortical perfusion following aneurysm clip application, 8 minutes prior to IONM alerts.
  • Perfusion dropped from 7.9% to 28.0% across six of the seven regions during ischemia.
  • Overall perfusion decrease from pre-ischemic to ischemic period was statistically significant with p<0.0001.

Cite This Study

Mercyshalinie et al. (2026) studied this question.

synapsesocial.com/papers/6a508afd6eeac72a4379ff36https://doi.org/10.1117/1.nph.13.3.035003
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